Voltarin as NSAID given with caution in patient with hypertension because it cause raising in blood pressure as following:-
1- Voltarin cause salt and water retention which lead to increase blood pressure.
2- Voltarin increase leukotrine by inhibiting cyclo oxygenase enzyme and leaving lipo oxygenase enzyme unopposed leading to release of leukotrine-4 (LT-4) and this by indirect way increase aldosterone which is the most known Na retaining hormone which lead to increase blood pressure .
3- Also voltarin as NSAID antagonize hypotensive effect of antihypertension drugs such as Beta blockers, Ca-channel blocker, clonidine, diazoxide, methyl dopa, mexonidine, nitrates and antagonize diuretic effect of diuretics and increase risk of hypertension and increase risk of hyperk NSAID alemia of k-sparing diuretics and aldosterone antagonist.
And any person with hypersion may use one or more thanone drug, so voltarin increase risk of hypertension and should be given with caution
Saturday, March 7, 2009
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