nIncomplete relaxation of lower sphincter during swallowing leading to functional obstruction and proximal dilatation
nAperistalsis, incomplete relaxation, increased resting tone
nGanglion cells of the myenteric plexus are diminished or absent
nClinical picture: dysphagia, regurgitation and aspiration
nHistology: Inflammation in the area of M. plexus
nHypotheses: autoimmune, viral infections
nMay occur secondary to Trypanosoma cruzi infection (Chagas disease)
n5% develop squamous cell carcinoma, at younger age
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